As a guy who lost 60 lbs in a little over a year on a high protein diet (then gained back 15 by just wavering a bit!) and is now on a low-fat diet, I was very interested in the current TIME cover on the state of research into Atkins vs Ornish and the research on weight loss in general. My sources tell me that the 60 I lost was primarily muscle and the replacement weight is fat. That matches up with my experience. I experienced a lot of high protein benefits in my overall feelings and condition, so I know the insulin connection was the real deal, but I just couldn’t see ingesting that much fat as a percentage of my diet for the rest of my life, so now I am doing 13% calories from fat and doing OK, though I no longer have all that sludge to eat without a guilty conscience!